منابع مشابه
Seeing peroxisomes
Seeing peroxisomes t about the same time that Christian de Duve and his colleagues were describing the biochemistry of lysosomes (see “Catching sight of lysosomes” JCB 168: 174), they biochemically identified (Baudhuin et al., 1965) and purified (Leighton et al., 1968) another enzyme-containing organelle. Initially the organelle was known as the microbody, and de Duve declined to give it a more...
متن کاملPartial disassembly of peroxisomes
Rat liver peroxisomes were subjected to a variety of procedures intended to partially disassemble or damage them; the effects were analyzed by recentrifugation into sucrose gradients, enzyme analyses, electron microscopy, and SDS PAGE. Freezing and thawing or mild sonication released some matrix proteins and produced apparently intact peroxisomal "ghosts" with crystalloid cores and some fuzzy f...
متن کاملHow proteins penetrate peroxisomes
Three decades after the unobtrusive debut of the peroxisome as a distinct subcellular organelle, biologists are paying attention to the special bag of tricks eukaryotic cells use to entice peroxisomal proteins from their site of synthesis in the cytosol to the peroxisome. In this minireview, we highlight some of the recent findings that have emerged, emphasize their significance, and contrast t...
متن کاملPeroxisomes and oxidative stress.
The discovery of the colocalization of catalase with H2O2-generating oxidases in peroxisomes was the first indication of their involvement in the metabolism of oxygen metabolites. In past decades it has been revealed that peroxisomes participate not only in the generation of reactive oxygen species (ROS) with grave consequences for cell fate such as malignant degeneration but also in cell rescu...
متن کاملMicrobodies: peroxisomes and glyoxysomes
Microbodies were first reported at the ultrastructural level in the proximal convoluted tubule ofmouse kidney by Rhodin in 1954 (1) and in hepatic parenchymal cells by Rouiller and Bernhard in 1956 (2) at about the time The Journal of Cell Biology was established . They were reported in plants by Porter and Caulfield in 1958 (3) and by Mollenhauer et al. in 1966 (4) . Microbodies are now recogn...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2011
ISSN: 0960-9822
DOI: 10.1016/j.cub.2011.07.024